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The Secretary shall determine the amount of a grant under paragraph (1) after considering—
(A) the amount of funds available for making the grants;
(B) the relative population of the State or outlying area;
(C) the types of activities proposed by the State or outlying area;
(D) the alignment of proposed activities with section 1412(a)(14) of this title;
(E) the alignment of proposed activities with the State plans and applications submitted under sections 6311 and 6611(d) 1 respectively, of this title; and
(F) the use, as appropriate, of scientifically based research activities.